ER1901-12
Scientist.com Supplier
Anti-DFNA5/GSDME Antibody
HuaBio
Image
Image
DESCRIPTION
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53.
Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity.
DETAILS
- Host: Rabbit
- Type: Primary
- Uniprot: SwissProt: O60443 Human;SwissProt: Q9Z2D3 Mouse;SwissProt: F1MAG0 Rat
- Clonality: Rabbit polyclonal Antibody
- Conjugate: Non-conjugated
- Alias Names: 2310037D07Rik antibody 4932441K13Rik antibody Deafness, autosomal dominant 5 antibody Deafness, autosomal dominant 5 protein antibody DFNA5 antibody DFNA5 gene antibody DFNA5_HUMAN antibody Dfna5h antibody EG14210 antibody Fin15 antibody ICERE 1 antibody ICERE-1 antibody Inversely correlated with estrogen receptor expression 1 antibody Non-syndromic hearing impairment protein 5 antibody Nonsyndromic hearing impairment protein antibody
- Application: WB,IHC-P,FC
- Epitope Region: Recombinant protein within Human DFNA5 / GSDME aa 1-220 / 496.
- Protein Target: ICERE-1, GSDME-NT, GSDME-CT, GSDME, DFNA5, ICERE1
- Target Species: Human,Mouse,Rat
- Species Reactivity: Human,Mouse,Rat