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71610

CD437

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)/t16-,17+,18-,27?
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs
  • Smiles: O=C(O)C1=CC2=CC=C(C3=CC(C4(C[C@@H]5C6)C[C@H](C5)C[C@H]6C4)=C(O)C=C3)C=C2C=C1
  • Inchikey: LDGIHZJOIQSHPB-PSAKPEQJSA-N
  • Cas Number: 125316-60-1
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C27H26O3
  • Formula Weight: 398.5
  • Shelf Life Days: 1460

DESCRIPTION

The prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of RARγ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively); cytotoxic various cancer cells through RAR-dependent and -independent signaling pathways