Human CD133 Full Length Protein, His Tag (Nanodisc)

DESCRIPTION

Human CD133 Full Length, His Tag (Nanodisc) (CD3-H52H1) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - His 865 (Accession # O43490-1).

DETAILS

Tag: C-10×His
Host: HEK293
Size: 20ug
Buffer: 50 mM HEPES, 150 mM NaCl, pH7.5
Format: Liquid
Purity: 90%
Storage: -70℃
Category: Bio-Markers & CD Antigens
Molecule: CD133
Accession: NP_006008.1
Conjugate: Unconjugated
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Background: Prominin-1 is also known as CD133, Antigen AC133, PROM1, PROML1 and MSTP061. Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation. May play a role in cell differentiation, proliferation and apoptosis . Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Exp Region: Gly 20 - His 865
Swiss-prot: O43490-1
Characteristics: The CD133 carries a polyhistidine tag at the C-terminus with calculated MW of 97.2 kDa and migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. The membrane scaffold protein (MSP1D1) has calculated MW of 24.7 kDa, and it migrates as 25 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 97.2 kDa
Shipping Condition: Dry ice
Species Reactivity: Human
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