E6641Hu
Human Tumor Necrosis Factor Receptor Superfamily Member 14, TNFRSF14 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed: 9462508, PubMed: 10754304, PubMed: 18193050, PubMed: 23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed: 19915044, PubMed: 9153189, PubMed: 9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed: 10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed: 23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed: 18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed: 19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed: 19915044) (By similarity). (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
DETAILS
- GeneID: 8764
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 30,392
- Synonyms: CD antigen CD270;Herpes virus entry mediator A;Herpesvirus entry mediator A;HveA;TNFRSF 14;TNFRSF14;TR2;Tumor necrosis factor receptor superfamily member 14;Tumor necrosis factor receptor-like 2;
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: TNFRSF14
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 4.37ng/L
- Target Protein: TNFRSF14
- Detection Range: 10-2000ng/L
- Full Product Name: Tumor Necrosis Factor Receptor Superfamily Member 14
- Standard Solution: 2400ng/L
- UniProt Accession: Q92956