PKA IIβ reg (phospho Ser113) rabbit pAb

DETAILS

Isotype: IgG
Category: Antibody
Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Clonality: Polyclonal
Immunogen: The antiserum was produced against synthesized peptide derived from human PKA-R2 beta around the phosphorylation site of Ser113. AA range:79-128
Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activ
Reactivity: Human;Mouse;Rat;Monkey
Applications: WB;IHC;IF;ELISA
Concentration: 1 mg/ml
Human Gene Id: 5577
Observed Bandkd: 46kD
Alternative Names: PRKAR2B; cAMP-dependent protein kinase type II-beta regulatory subunit
Storage Stability: -20°C/1 year
Human Swiss Prot No: P31323
Subcellular Location: Cytoplasm . Cell membrane . Colocalizes with PJA2 in the cytoplasm and at the cell membrane.