BEK1118
Human IL-12 P70
Biospes
DESCRIPTION
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. It mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. IL12 p40 exists as a monomer and as a homodimer. The IL12B gene contains 8 exons, and maps to 5q31-q33.
DETAILS
- OMIM: 161561
- Gene ID: 3592, 3593
- SwissProt: P29459, P29460
- Test Range: 7.8 pg/ml-500 pg/ml
- Alias Names: Interleukin 12, Interleukin-12, IL-12, IL12, IL 12, Interleukin 12 P70 subunit, Interleukin 12 p70, il-12p70, il-12-p70, il12p70, p70
- Application: Quantitative ELISA
- Sensitivity: < 2pg/ml
- Test Samples: For quantitative detection of IL-12(P70) in human serum, body fluids, tissue lysates or cell culture supernatants.
- Detection Method: Sandwich Enzyme-Linked Immune-sorbent Assay
- Species Reactivity: Human
- Storage Instruction: Store at 2-8℃ for 6 months, or at -20℃ for 12 months.