Fluorescent Dye Label: DiD Surface Coating: Methoxy PEG Amount: 20 mg Description Our single-layer poly (lactic-co-glycolic acid) (PLGA) nanoparticles form nanostructures with a hydrophobic core encapsulated inside a hydrophilic shell. Dye molecules are encapsulated inside the hydrophobic core. PLGA surface contains COOH groups that can be used for EDC/NHS based bioconjugation. Optional surface modifications include methoxy PEG (improves in vivo blood half-life) and PEG-Azide (can be used to covalently attach biomolecules by click chemistry) Features Made with FDA approved biocompatible and biodegradable PLGA polymer. Conjugation-ready for covalent attachment of biomolecules. High degree of monodispersity. Labeled with a fluorescent dye. (Optional) Incorporation of Methoxy-PEG minimizes non-specific protein adsorption. This increase nanoparticle in-vivo blood half-life. (Optional) Incorporation of Azide-PEG allows conjugation of proteins and small molecules by click chemistry. Applications Fluorescence labeled nanoparticles for in vitro and in-vivo targeting. Fluorescence imaging for in vitro and in vivo applications. Fluorescence probes for flowcytometry analysis. In vitro and in vivo delivery of proteins and small molecules. Product is supplied as lyophilized powder.