B0084-463202
Cathepsin S inhibitor
BOC Sciences
DESCRIPTION
Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases.
DETAILS
- Smiles: CNC(=O)OC1COC2=C(C1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5
- Aliases: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor
- Cas Number: 1373215-15-6
- Molecular Weight: 484.52
- Molecular Formula: C25H29FN4O5