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sc-514480 HRP

Scientist.com Supplier

N-RAP (H-5) HRP

Santa Cruz Biotechnology

DESCRIPTION

mouse monoclonal IgG1; N-RAP Antibody (H-5) is an IgG1 κ mouse monoclonal N-RAP antibody (also designated N-RAP antibody) that detects the N-RAP protein of mouse, rat and human origin by WB, IP, IF and ELISA. N-RAP Antibody (H-5) is available as both the non-conjugated anti-N-RAP antibody form, as well as multiple conjugated forms of anti-N-RAP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Nebulin is a large filamentous protein specific to muscle tissue that may function as a "ruler" for actin filament length. N-RAP (nebulin-related anchoring protein) is a 1,730 amino acid protein that may play a role in myofibril assembly and in mediating force transmission in cardiomyocytes. N-RAP localizes to the intercalated disks of cardiac muscle and the myotendinous junctions of skeletal muscle, where it is exclusively expressed. Existing as four alternatively spliced isoforms, N-RAP contains one N-terminal LIM domain and fourty-four nebulin repeats. N-RAP binds α-actinin and Filamin 2 during myofibril assembly and is also known to interact with Actin, KBTBD10, Talin-1 and vinculin. The gene encoding N-RAP maps to human chromosome 10q25.3 and mouse chromosome 19 D2.

DETAILS

  • Host: mouse
  • Type: Primary
  • Uniprot: Q86VF7
  • Clonality: Monoclonal
  • Conjugate: HRP
  • Applications: WB, IHC(P), ELISA
  • Human Gene Id: 4892
  • Mouse Gene Id: 18175
  • Protein Target: N-RAP
  • Human Gene Name: NRAP
  • Mouse Gene Name: Nrap
  • Species Reactivity: mouse, rat, human