DESCRIPTION

• Target: UT-A1
• Gene Id: 54302
• Conjugate: FITC
• Immunogen: Produced against a synthetic peptide mapped to the C-terminal tail (amino acids 911-929) of rat UT-A1 (antibody designation L194)
• References: 1. Nielsen S., et al. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500. 2. Smith C.P. (2009) Exp Physiol. 94(2): 180-185.
• Swiss-prot: Q62668
• Specificity: Detects ~97 and 127kDa.
• Applications: WB | ICC/IF | IHC
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Rabbit
• Product Type: Polyclonal
• Purification: Peptide Affinity Purified
• Concentration: 1 mg/ml
• Research Areas: Neuroscience | Pumps/Transporters | Urea Transporters
• Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_062220
• Alternative Names: SLC14A2 Antibody, FLJ16167 Antibody, hUT-A6 Antibody, HUT2 Antibody, kidney Antibody, MGC119566 Antibody, MGC119567 Antibody, Slc14a2 Antibody, Solute carrier family 14 (urea transporter) Antibody, member 2 Antibody, Solute carrier family 14 member 2 Antibody, Urea transporter 2 Antibody, Urea transporter Antibody, Urea transporter kidney Antibody, UT-A2 Antibody, UT2 Antibody, UT2_HUMAN Antibody, UTA Antibody, UTR Antibody, UT1 Antibody, UTA1 Antibody
• Antibody Dilution: WB (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SPC-406D-FITC, RRID: AB_2704601
• Immunogen Species: Rat
• Tissue Specificity: Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. Isoform 3 and isoform 4 are expressed in both the inner and outer renal medulla.
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Cell Membrane | Apical Cell Membrane
• Scientific Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2) (1, 2).
• Certificate of Analysis: 1 µg/ml of SPC-406 was sufficient for detection of UT-A1 in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Rat | Mouse