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21904

Yoda1

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Blood
  • Smiles: ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CN=CC=N3)S2
  • Inchikey: BQNXBSYSQXSXPT-UHFFFAOYSA-N
  • Cas Number: 448947-81-7
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C13H8Cl2N4S2
  • Formula Weight: 355.3
  • Shelf Life Days: 1460

DESCRIPTION

A Piezo1 channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively); selective for Piezo1 as it elicits Ca2+ flux in Piezo1- but not Piezo2-transfected HEK293T cells; slows the inactivation phase of murine Piezo1 transient currents and sensitizes them to activation by mechanical pressure; induces dehydration and a change in shape of wild-type red blood cells but not Piezo1 knockout cells