1128234-50mg 1128234-10mg
endo-IWR-1
Biogems
DESCRIPTION
Endo-IWR-1 is a Wnt pathway inhibitor that stabilizes the axis inhibition protein 2 (AXIN2) or conductin. It is reported to maintain pluripotency of human embryonic stem cells when used with CHIR99021 and promote Beta-catenin phosphorylation.
DETAILS
- Purity: ≥98%
- Synonyms: IWR-1-endo, IWR-1, IWR1-endo
- Cas Number: 1127442-82-3
- References: Huang, S. M. A., Mishina, Y. M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G. A., ... & Cong, F. (2009). Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature, 461(7264), 614-620. Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Bao, R., Christova, T., Song, S., Angers, S., Yan, X., & Attisano, L. (2012). Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
- Molecular Weight: 409.4
- Molecular Formula: C25H19N3O3
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6