mouse monoclonal IgG2a; DMPK Antibody (9-RY26) is an IgG2a κ mouse monoclonal DMPK antibody (also designated DMPK antibody) that detects the DMPK protein of human origin by WB, IP and ELISA. DMPK Antibody (9-RY26) is available as the non-conjugated anti-DMPK antibody. Myotonic dystrophy protein kinase (DMPK) is a multi-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis. DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction. DM arises through expansion of CTG repeats in the 3′-UTR of the DMPK gene. Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus. These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype. Other substrates for DMPK include myogenin, L-type calcium channels, and Phospholemman (PLM).

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.