NMNAT1 Blocking Peptide (C-Term)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 64802
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: NMNAT1
Other Names: Nicotinamide mononucleotide adenylyltransferase 1, NMN adenylyltransferase 1, 2.7.7.1, Nicotinate-nucleotide adenylyltransferase 1, NaMN adenylyltransferase 1, 2.7.7.18, NMNAT1, NMNAT
Availability: 2 weeks
Bio Background: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Bio References: Schweiger M.,et al.FEBS Lett. 492:95-100(2001). Emanuelli M.,et al.J. Biol. Chem. 276:406-412(2001). Fernando F.S.,et al.Gene 284:23-29(2002). Ota T.,et al.Nat. Genet. 36:40-45(2004). Gregory S.G.,et al.Nature 441:315-321(2006).
Other Accession: Q0VD50;Q9EPA7
Primary Accession: Q9HAN9
Targetspecificity: The synthetic peptide sequence is selected from aa 220-232 of HUMAN NMNAT1