2088055-50mg 2088055-10mg
DAPT
Biogems
DESCRIPTION
DAPT is a potent inhibitor of the gamma-secretase complex, which is an internal protease that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. DAPT also indirectly inhibits the Notch protein. It is reported promote neuronal differentiation and enhance the apoptosis of human tongue carcinoma cells.
DETAILS
- Purity: ≥95%
- Synonyms: gamma-Secretase Inhibitor IX, GSI IX, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester
- Cas Number: 208255-80-5
- References: El Mouedden, M., Vandermeeren, M., Meert, T., & Mercken, M. (2005). Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. Current pharmaceutical design, 12(6), 671-676. Yagishita, S., Morishima-Kawashima, M., Tanimura, Y., Ishiura, S., & Ihara, Y. (2006). DAPT-induced intracellular accumulations of longer amyloid β-proteins: further implications for the mechanism of intramembrane cleavage by γ-secretase. Biochemistry, 45(12), 3952-3960. Crawford, T. Q., & Roelink, H. (2007). The Notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell‐derived embryoid bodies independently of sonic hedgehog signaling. Developmental Dynamics,236(3), 886-892. Grottkau, B. E., Friedrich, C. C., Jing, W., & Wu, Y. (2009). DAPT enhances the apoptosis of human tongue carcinoma cells. International journal of oral science, 1(2), 81-89.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
- Molecular Weight: 432.5
- Molecular Formula: C23H26F2N2O4
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F