mouse monoclonal IgG1; Csk Antibody (E-3) is an IgG1 κ mouse monoclonal Csk antibody (also designated CSK Non-Receptor Tyrosine Kinase antibody, Tyrosine-Protein Kinase CSK antibody, Protein-Tyrosine Kinase CYL antibody, C-Src Tyrosine Kinase antibody, or C-Src Kinase antibody) that detects the Csk protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Csk Antibody (E-3) is available as both the non-conjugated anti-Csk antibody form, as well as multiple conjugated forms of anti-Csk antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.