30-2627
Anti-Mouse CD2 FITC (Clone : RM2-5)
Abeomics
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DESCRIPTION
CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.Specificity : The rat monoclonal antibody RM2-5 recognizes an extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.
DETAILS
- Gene: CD2
- App Id: FACS
- Antigen: CD2
- Gene Id: 12481
- Isotype: Rat IgG2b lambda
- Clone Name: RM2-5
- Clonality Id: Monoclonal
- Conjugate Id: FITC
- Purification: The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivity Id: Mouse
- Product Content: 0.5 mg/mlFormulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
- Alternative Name: LFA-2, Ly37, Ly-37,CD2 molecule
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: Murine thymocytes
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