ARGBP2 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 8470
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SORBS2
Other Names: Sorbin and SH3 domain-containing protein 2, Arg/Abl-interacting protein 2, ArgBP2, Sorbin, SORBS2, ARGBP2, KIAA0777
Availability: 2 weeks
Bio Background: Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. ARGBP2 is the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology(SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.
Bio References: Yuan,Z.Q.,et.al., J. Biol. Chem. 280 (22), 21483-21490 (2005)Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)Taieb,D., et.al., Cancer Res. 68 (12), 4588-4596 (2008)
Primary Accession: O94875
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP6997a was selected from the N-term region of human ARGBP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.