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28293

NI-42

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains
  • Smiles: O=S(C1=CC=C(C#N)C=C1)(NC2=CC(C=C(C)C(N3C)=O)=C3C=C2)=O
  • Inchikey: BMVCSXFOQPYKKC-UHFFFAOYSA-N
  • Cas Number: 1884640-99-6
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C18H15N3O3S
  • Formula Weight: 353.4
  • Shelf Life Days: 1460

DESCRIPTION

An inhibitor of the BRPF1 bromodomain (IC50 = 7.9 nM); selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively); inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 AML cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 µM, respectively) and a variety of non-AML cells (GI50s = 1-10 µM); also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 µM, respectively)