Polyclonal Antibody to FAK (Ab-861)

DESCRIPTION

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by igands such as bombesin or ysophosphatidic acid, or via DL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

DETAILS

Gene: PTK2
App Id: WB,IHC
Antigen: FAK (Ab-861)
Gene Id: 5747
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: Q05397
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: FADK 1|| FAK1|| PTK2
Application Note: Predicted MW: 125kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around aa. 859~863 (H-I-Y-Q-P) derived from Human FAK.