mouse monoclonal IgG1; Bak Antibody (C-3) is an IgG1 κ mouse monoclonal Bak antibody that detects Bak of human origin by WB, IP, IF and ELISA. Bak Antibody (C-3) is available as the non-conjugated anti-Bak antibody form, as well as multiple conjugated forms of anti-Bak antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis, while other members of the Bcl-2 family, such as Bax, accelerate death under various conditions. One member of the Bcl-2 family, designated Bak, functions primarily to enhance apoptotic cell death following appropriate activating signals and, in addition, counteracts the protection from apoptosis provided by Bcl-2. Expression of Bak is widespread in a broad range of cells, including various long-lived, terminally differentiated cell types, suggesting that its cell-death- inducing activity is broadly distributed and that the regulation of inhibitors of apoptosis may represent an important determinant of tissue-specific modulation of apoptosis.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.