Polyclonal Antibody to FAK (Phospho-Tyr397)

DESCRIPTION

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by igands such as bombesin or ysophosphatidic acid, or via DL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

DETAILS

Gene: PTK2
App Id: WB
Antigen: FAK (Phospho-Tyr397)
Gene Id: 5747
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: Q05397
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human,Mouse,Rat
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: FAK|| FAK1|| PTK2
Application Note: Predicted MW: 125kd, Western blotting: 1:500~1:1000
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around phosphorylation site of tyrosine 397(D-D-Y(p)-A-E)derived from Human FAK.