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Recombinant Rat SDF-1beta (CXCL12)



  • Gene Id: 24772
  • Uniprot: Q9QZD1
  • Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 100.0-200.0 ng/ml.
  • Category: RUO Cytokines
  • Subcategory: Chemokines
  • Research Areas: AIDS/HIV, Chemotaxis, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation, Wound Healing
  • Alternative Names: Stromal-Cell Derived Factor-1, CXCL12, PBSF
  • Species of Origin: Rat
  • Expression System Source: E.coli


SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1beta protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Rat SDF-1beta is an 8.4 kDa protein containing 72 amino acid residues.