1083707-50mg 1083707-5mg
GSK923295
Biogems
DETAILS
- Purity: ≥98%
- Synonyms: GSK-923295
- Cas Number: 1088965-37-0
- References: Chung, V., Heath, E. I., Schelman, W. R., Johnson, B. M., Kirby, L. C., Lynch, K. M., ... & Holen, K. D. (2012). First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer chemotherapy and pharmacology, 69(3), 733-741. Qian, X., McDonald, A., Zhou, H. J., Adams, N. D., Parrish, C. A., Duffy, K. J., ... & Jiang, H. (2010). Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295. ACS medicinal chemistry letters, 1(1), 30-34. Wacker, S. A., & Kapoor, T. M. (2010). Targeting a kinetochore-associated motor protein to kill cancer cells. Proceedings of the National Academy of Sciences, 107(13), 5699-5700.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide
- Molecular Weight: 592.1
- Molecular Formula: C32H38ClN5O4
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C)OC1=C(C=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)C3=CN4C=CC=C(C4=N3)C(C)O)CNC(=O)CN(C)C)Cl
DESCRIPTION
GSK923295 is a potent and selective mitotic kinesin Centromere protein E (CENP-E) inhibitor, a protein that accumulates in the G2 phase of the cell cycle. It is proposed to be one of the motors responsible for mammalian chromosome movement and spindle elongation. GSK923295 induces mitotic arrest and chromosome alignment failure. It is reported to be a potent inhibitor of tumor cell growth, which is further enhanced when MEK/ERK signaling is also inhibited.