E0056Hu
Scientist.com Supplier
Human Interleukin 28A, IL-28A ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
DETAILS
- Gene Id: 282616
- Uniprot: Q8IZJ0
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 9.51ng/L
- Detection Range: 20-3800ng/L
- Detection Method: ELISA
- Species Reactivity: Human