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E0056Hu

Human Interleukin 28A, IL-28A ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

DETAILS

  • GeneID: 282616
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 22,288
  • Synonyms: Cytokine Zcyto20;IFN-lambda-2;IL 28A;IL28A;IL-28A;Interferon lambda-2;Interleukin-28A
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: IL28A
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 9.51ng/L
  • Target Protein: IL28A
  • Detection Range: 20-3800ng/L
  • Full Product Name: Interleukin 28A
  • Standard Solution: 4000ng/L
  • UniProt Accession: Q8IZJ0