Sanggenone C

DESCRIPTION

A flavonoid with diverse biological activities; inhibits TNF-α- or IL-1β-induced PMN adhesion to HSCs (IC50s = 27.29 and 54.43 nM, respectively); inhibits NF-κB activation in HSCs; induces apoptosis and production of ROS in HT-29 cells from 10-40 µM; decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model at 10 mg/kg; increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis; attenuates cardiac hypertrophy and fibrosis and reduces activation of NFAT2 in a mouse model of pressure overload-induced cardiac hypertrophy

DETAILS

Inchi: InChI=1S/C40H36O12/c1-18(2)10-11-39-27-9-6-22(43)16-31(27)52-40(39,50)38(49)35-32(51-39)17-30(46)34(37(35)48)26-13-19(3)12-25(23-7-4-20(41)14-28(23)44)33(26)36(47)24-8-5-21(42)15-29(24)45/h4-10,13-17,25-26,33,41-46,48,50H,11-12H2,1-3H3/t25-,26+,33-,39-,40-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity
Smiles: O=C1[C@]2(O)[C@](C3=CC=C(O)C=C3O2)(C/C=C(C)\C)OC4=C1C(O)=C([C@]5([H])[C@H](C(C6=C(O)C=C(O)C=C6)=O)[C@](C7=CC=C(O)C=C7O)([H])CC(C)=C5)C(O)=C4
Inchikey: XETHJOZXBVWLLM-HUKCQOFTSA-N
Cas Number: 80651-76-9
Formulation: A crystalline solid
Item Origin: Plant/Cortex Mori Radicis
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C40H36O12
Formula Weight: 708.7
Shelf Life Days: 1460