RC233-20
M-CSF, mouse, 10ug
Bio Basic
DESCRIPTION
M-CSF, murine (mouse): Macrophage Colony Stimulating Factor (M-CSF), also named CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. It is produced by osteoblasts (as a result of endocrine stimulation by parathyroid hormone) exerts paracrine effects on osteoclasts and can interact with CSF1R. M-CSF is a four α-helical bundle cytokine and its active form is found extracellularly as a disulfide-linked homodimer. Four transcript variants encoding three different isoforms have been reported for M-CSF gene. Although forms may vary, all of them contain the N-terminal 150 a.a. portion that is necessary and sufficient for interaction with the receptor. The first 229 a.a. of mature mouse M-CSF shares 87 %, 83 %, 82 % and 81 % sequence identity with corresponding regions of rat, dog, cow and human M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific. UnitProt ID: Q3U4F9
DETAILS
- Bbi Code Sku: RC233-20.SIZE.10ug
- Storage Conditions: (-15 to -20)C
- Tags Search Keywords: Recombinant Proteins M-CSF, mouse, 10ug
- Product Category Level 1: Proteins
- Product Category Level 2: Recombinant Proteins
- Shipping Conditions Rtice: ICE
- Refrigeration Requirements: Freezer