26210
Scientist.com Supplier
HMN-214
Cayman Chemical
DESCRIPTION
A prodrug form of the PLK inhibitor HMN-176; decreases MDR1 expression in AB-A.1 cells and in tumors isolated from mice bearing multidrug resistant KB-A.1. xenografts; reduces tumor volume in PC3, WiDr, and A549 mouse xenograft models at 20 mg/kg per day; does not induce nerve toxicity in rabbit sciatic nerves in vivo at 30 mg/kg per day
DETAILS
- Inchi: InChI=1S/C22H20N2O5S/c1-17(25)24(30(27,28)21-11-9-20(29-2)10-12-21)22-6-4-3-5-19(22)8-7-18-13-15-23(26)16-14-18/h3-16H,1-2H3/b8-7+
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Kinase Inhibitors|Plks||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death||Research Area|Cancer|Multidrug Resistance
- Smiles: [O-][N+]1=CC=C(/C=C/C2=CC=CC=C2N(C(C)=O)S(C3=CC=C(OC)C=C3)(=O)=O)C=C1
- Inchikey: OCKHRKSTDPOHEN-BQYQJAHWSA-N
- Cas Number: 173529-46-9
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C22H20N2O5S
- Formula Weight: 424.5
- Shelf Life Days: 1460