Anti-ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody(Clone: ERb455)-CF488

DESCRIPTION

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, thoµgh some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence sµggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even thoµgh they share many functional characteristics.

DETAILS

Gene: ESR2
App Id: FACS,IF
Gene Id: 2100
Isotype: Mouse IgG2a, kappa
Clone Name: ERb455
Uniprot Id: Q92731
Host Animal: Mouse
Clonality Id: Monoclonal
Conjugate Id: CF488
Reactivity Id: Human, Mouse, Rat
Product Content: Antibody Purified from Bioreactor Concentrate by Protein A/G and conjµgated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.
Alternative Name: Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4
Application Note: Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood);Immunofluorescence (1:50-1:100);
Storage Condition: Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: C-terminus fragment of recombinant human estrogen receptor beta protein