DESCRIPTION

• Shiptemp: -80°C (dry ice)
• Synonyms: stem cell factor kit
• Warnings: Avoid freeze/thaw cycles.
• Category: Kinase/Assay Kit
• Background: c-KIT is a proto-oncogene and a type III transmembrane receptor for mast cell growth factor, also known as stem cell factor. It plays an essential role in the regulation of cell survival and proliferation, as well as hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and mast cell development, migration and function. Activating mutations in cKIT are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, and acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.
• References: 1. Picardo, M., Cardinali, G. J Invest Dermatol. 2011 Jun; 131(6): 1182-5. 2. Yarden, Y., et al. EMBO J. 1987; 6(11): 3341-51.
• Description: The cKIT Assay Kit is designed to measure cKIT activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
• Methodology: Chemiluminescent
• Supplied As: The cKIT Assay Kit comes in a convenient 96-well format, with enough purified recombinant cKIT enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.
• Unspsc Code: 41105332
• Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
• Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
• Product Type: Assay Kit
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 40252, 40250, 40217, 79686, 78487
• Storage Stability: Up to 6 months when stored as recommended.
• Scientific Category: Kinase
• Instructions for Use: See assay protocol for detailed instructions.