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LDN193189 Hydrochloride
Biogems
DESCRIPTION
LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification. The salt-based form of LDN193189 has higher solubility in DMSO than LDN193189 (cat# 1062443).
DETAILS
- Purity: ≥98%
- Synonyms: LDN-193189 hydrochloride, LDN193189 HCl
- Cas Number: 1062368-62-0
- References: Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807 Kreitzer, F. R., Salomonis, N., Sheehan, A., Huang, M., Park, J. S., Spindler, M. J., ... & Conklin, B. R. (2013). A robust method to derive functional neural crest cells from human pluripotent stem cells. American journal of stem cells,2(2), 119. Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., ... & Paul, B. Y. (2012). Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 32(3), 613-622.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;hydrochloride
- Molecular Weight: 443
- Molecular Formula: C25H22N6 HCl
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl