23481
KM 11060
Cayman Chemical
DESCRIPTION
A F508del-CFTR corrector; increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 μM; restores F508del-CFTR function in CFBE41o- human airway epithelial cells at a concentration of 10 nM; restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 μM
DETAILS
- Inchi: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Ion Channel Modulation||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Cystic Fibrosis
- Smiles: ClC1=CC=C(S(N2CCN(C3=CC=NC4=C3C=CC(Cl)=C4)CC2)(=O)=O)C=C1
- Inchikey: GIEHIZKCIZLXLF-UHFFFAOYSA-N
- Cas Number: 774549-97-2
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C19H17Cl2N3O2S
- Formula Weight: 422.3
- Shelf Life Days: 1460