PTPIA2 beta Antibody (N-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5799
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PTPRN2
Other Names: Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387
Availability: 2 weeks
Bio Background: PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.
Bio References: Schmidli, R.S., et al., Autoimmunity 28(1):15-23 (1998).Li, Q., et al., Proc. Assoc. Am. Physicians 109(4):429-439 (1997).Cui, L., et al., J. Biol. Chem. 271(40):24817-24823 (1996).Kawasaki, E., et al., Biochem. Biophys. Res. Commun. 227(2):440-447 (1996).Smith, P.D., et al., Biochem. Biophys. Res. Commun. 229(2):402-411 (1996).
Primary Accession: Q92932
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP8427a was selected from the N-term region of human PTPIA2beta . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.