mouse monoclonal IgG1; DSCR 1 Antibody (G-2) is an IgG1 κ mouse monoclonal DSCR 1 antibody (also designated DSCR 1 antibody) that detects the DSCR 1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. DSCR 1 Antibody (G-2) is available as both the non-conjugated anti-DSCR 1 antibody form, as well as multiple conjugated forms of anti-DSCR 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. DSCR1 (Down syndrome critical region 1), also known as Calcipressin-1, Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.