30-2239
PE Conjugated, Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)
Abeomics
DESCRIPTION
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
DETAILS
- Gene: ENG
- App Id: FACS
- Antigen: CD105
- Gene Id: 2022
- Isotype: Mouse IgG2a
- Clone Name: MEM-229
- Uniprot Id: P17813
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Reactivity Id: Human
- Alternative Name: ENG||END
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
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