ZL0420

DESCRIPTION

A BRD4 inhibitor; inhibits BD1 and BD2 in BRD4 (IC50s = 27 and 32 nM, respectively); selective for BD1 and BD2 in BRD4 over BD1 in BRD2, BRD3, and BRDT (IC50s = 803, 2,275, and 3,183 nM, respectively) and BD2 (IC50s = 1,736, 2,193, and 2,781 nM, respectively), as well as the bromodomain in CBP (IC50 = >10,000 nM); inhibits neutrophil infiltration around small- and medium-sized airways and reduces cytokine expression in lung tissue in a poly(I:C)-induced mouse model of acute airway inflammation at 10 mg/kg

DETAILS

Inchi: InChI=1S/C16H16N4O2/c1-9-6-14(12(17)8-15(9)21)20-19-11-3-4-13-10(7-11)2-5-16(22)18-13/h3-4,6-8,21H,2,5,17H2,1H3,(H,18,22)/b20-19+
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Pulmonary Diseases
Smiles: OC1=C(C)C=C(/N=N/C2=CC(CCC(N3)=O)=C3C=C2)C(N)=C1
Inchikey: ANMQADUROYWADA-FMQUCBEESA-N
Cas Number: 2229039-45-4
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C16H16N4O2
Formula Weight: 296.3
Shelf Life Days: 1460