DESCRIPTION

• Tag: mGFP
• Accn: NM_011183
• Type: Mouse Tagged ORF Clone
• Refseq: NM_011183.2
• Status: 7 Weeks*
• Symbol: Psen2
• Vector: pLenti-C-mGFP-P2A-Puro
• Category: cDNA Clones
• Locus Id: 19165
• Orf Size: 1344 bp
• Synonyms: Ad4; Ad4h; ALG; ALG-3; Alg3; P; PS; PS-2; PS2; Psnl2; STM2
• Refseq Orf: 1347 bp
• Uniprot Id: Q61144
• Refseq Size: 1991 bp
• Availability: 7 Weeks
• Cytogenetics: 1 84.19 cM
• Gene Summary: This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]
• Sequence Data: ORF Nucleotide Sequence ( show hide ) The ORF insert of this clone is exactly the same as(MR222924).
• Oti Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Oti Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Mammalian Cell Selection: Puromycin