Human Semaphorin 4D / SEMA4D / CD100 Protein, Fc Tag

DESCRIPTION

Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

DETAILS

Tag: C-Fc
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 100 mM Glycine, pH7.5
Format: Powder
Purity: 95%
Source: Human SEMA4D, Fc Tag (CD0-H5257) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Arg 734 (Accession # AAH54500).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Semaphorin 4D
Accession: AAH54500
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 22 - Arg 734
Swiss-prot: Q92854
Package Size: 250ug*4
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 105.4 kDa. The protein migrates as 125-160 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 105.4 kDa
Shipping Condition: RT
Species Reactivity: Human
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