DESCRIPTION

• Tag: C-10×His | Native
• Host: HEK293
• Size: 100ug
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Format: Powder
• Purity: 90%
• Storage: -20℃
• Category: Bio-Markers & CD Antigens
• Molecule: Integrin alpha 2 beta 1
• Accession: NP_032422.2 | NP_034708.1
• Conjugate: Unconjugated
• Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Background: Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.
• Exp Region: Tyr 27 - Thr 1129 (ITGA2) & Gln 21 - Asp 728 (ITGB1)
• Swiss-prot: Q62469-1 (ITGA2) & P09055-1 (ITGB1)
• Characteristics: Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA2 and ITGB1, has a calculated MW of 127.6 kDa (ITGA2) and 83.5 kDa (ITGB1). Subunit ITGA2 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 140-150 kDa (ITGA2) and 100-130 kDa (ITGB1) respectively due to glycosylation.
• Endotoxin Level: 1.0 EU per μg
• Molecular Weight: 127.6 kDa (ITGA2) & 83.5 kDa (ITGB1)
• Shipping Condition: RT
• Species Reactivity: Mouse
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