T10453
BACE1-IN-5
TargetMol
DESCRIPTION
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-β (Aβ) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].
DETAILS
- Cas: 2581114-83-0
- Purity: 98%
- Smiles: C[C@]1(C[C@@H](C(F)(F)F)SC(N)=N1)C2=CC(NC(=O)C=3C=NC(OCF)=CN3)=CC=C2F
- Category: Compound
- Molecular Weight: 461.41
- Molecular Formula: C18H16F5N5O2S
Lead Time: 4 - 5 weeks
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