DESCRIPTION

• Tag: N-10×His & N-Avi
• Host: HEK293
• Size: 25ug
• Buffer: PBS, pH7.4
• Format: Powder
• Purity: 90%
• Storage: -20℃
• Category: MABSol® Biotin Labeled Proteins
• Molecule: IL-31
• Accession: NP_083870.1
• Conjugate: Biotin-labeled
• Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Background: IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
• Exp Region: Thr 24 - Cys 163
• Swiss-prot: Q6EAL8-1
• Characteristics: This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 19.2 kDa. The protein migrates as 20-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin Level: 1.0 EU per μg
• Molecular Weight: 19.2 kDa
• Shipping Condition: RT
• Species Reactivity: Mouse
• Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html