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Cayman Chemical

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  • Inchi: InChI=1S/C23H22N8O/c1-14-15(11-24)6-4-8-17(14)18-10-19(28-22(25)27-18)20-13-31(30-29-20)12-16-7-5-9-21(26-16)23(2,3)32/h4-10,13,32H,12H2,1-3H3,(H2,25,27,28)
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Immunology||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity
  • Smiles: N#CC1=CC=CC(C2=NC(N)=NC(C3=CN(CC4=CC=CC(C(C)(O)C)=N4)N=N3)=C2)=C1C
  • Cas Number: 2239273-34-6
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C23H22N8O
  • Formula Weight: 426.5
  • Shelf Life Days: 1460


An adenosine A2A and A2B receptor dual antagonist; inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro; reduces tumor growth in an AT3-OVA syngeneic mouse model alone or in combination with doxorubicin; acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model