mouse monoclonal IgG1; Aldolase C Antibody (H-11) is an IgG1 κ mouse monoclonal Aldolase C antibody (also designated ALDOC antibody, ALDC antibody, Fructose-bisphosphate aldolase C antibody, or Brain-type aldolase antibody) that detects the Aldolase C protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Aldolase C Antibody (H-11) is available as both the non-conjugated anti-Aldolase C antibody form, as well as multiple conjugated forms of anti-Aldolase C antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Fructose 1,6-bisphosphate aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate. Fructose 1,6-bisphosphate aldolase exists as three forms, the muscle-specific Aldolase A, the liver-specific aldolase B, and the brain-specific aldolase C. Aldolase A, B, and C arose from a common ancestral gene, from which aldolase B first diverged. Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagon and has been implicated in hereditary fructose intolerance disease (3,5). Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells (6,8-10). Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells (7,10).