mouse monoclonal IgG2a; NELF-D Antibody (C-10) is an IgG2a κ mouse monoclonal NELF-D antibody (also designated NELFCD antibody or NELFD antibody) that detects the NELF-D protein of mouse, rat and human origin by WB, IP, IF and ELISA. NELF-D Antibody (C-10) is available as both the non-conjugated anti-NELF-D antibody form, as well as multiple conjugated forms of anti-NELF-D antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. NELF-D (negative elongation factor C/D), also known as TH1, NELF-C, HSPC130 or TH1L, is a 590 amino acid protein that localizes to the nucleus and exists as a component of the multi-protein NELF complex, a structure which negatively regulates Pol II-dependent transcription elongation. Expressed in a variety of tissues, including liver, heart, kidney, lung, brain, placenta and pancreas, NELF-D is involved in controlling transcriptional pausing of Pol II and may be able to induce chromatin unfolding, possibly playing a role in tumorigenesis. NELF-D is encoded by a gene which maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.