ACC-003_25 mcl ACC-003_50 mcl ACC-003_0.2 ml ACC-003-CF_0.2 ml
Scientist.com Supplier
Anti-CaV1.2 (CACNA1C) Antibody
Alomone Labs
Image
Image
Image
Image
Image
Image
Image
Image
Image
DESCRIPTION
Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, immunocytochemistry, and indirect flow cytometry applications. It has been designed to recognize CaV1.2 from mouse, rat, and human samples.
DETAILS
- Form: Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
- Host: Rabbit
- Clone: NA
- Label: Unconjugated
- Purity: Affinity purified on immobilized antigen.
- Target: Voltage-dependent L-type calcium channel subunit α1C
- Comment: Contact Alomone Labs for technical support and product customization
- Gene Id: 24239
- Isotype: Rabbit IgG
- Homology: Mouse - identical; guinea pig - 17/18 amino acid residues identical; human, rabbit - 16/18 amino acid residues identical
- Is Toxin: No
- Sequence: (C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat CaV1.2
- Synonyms: Voltage-dependent L-type calcium channel subunit α1C
- Accession: P22002
- Clonality: Polyclonal
- Lead Time: 1-2 Business Days
- Reactivity: Human|Rat|Mouse
- Formulation: PBS pH7.4
- Applications: IC|IF|IFC|IHC|WB
- Ko-validated: yes
- Preservative: No Preservative
- Reconstitution: 0.2 ml double distilled water (DDW).
- Blocking Peptide: BLP-CC003
- Negative Control: BLP-CC003
- Positive Control: NA
- Cited Application: IP|IHC|ICC
- Immunogen Location: Intracellular loop between domains II and III
- Peptide Confirmation: Confirmed by amino acid analysis and mass spectrometry
- Shipping and Storage: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
- Immunogen Source Species: Rat
- Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
- Antigen Preadsorption Control: 1 µg peptide per 1 µg antibody
- Applications May Also Work In: IC|IF|IFC|IHC|WB
- Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
- Product Page - Scientific Background: All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal, cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors.While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in the heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channel blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700).
- Standard Quality Control of Each Lot: Western blot analysis
- Application Dilutions Western Blot Wb: 1:200
- Product Page Antibodies Part of Immunogen: Product Page antibodies - Part of Immunogen
- Antibody Concentration After Reconstitution: 1 mg/ml
- Application Dilutions Immunohistochemistry Paraffin Embedded Sections Ihc: Contact Alomone for information