mouse monoclonal IgG1; EMP-3 Antibody (SW-5) is an IgG1 κ mouse monoclonal EMP-3 antibody (also designated EMP-3 antibody) that detects the EMP-3 protein of human origin by WB, IP, IF, IHC(P) and ELISA. EMP-3 Antibody (SW-5) is available as the non-conjugated anti-EMP-3 antibody. EMP-3 (epithelial membrane protein 3), also known as YMP, is a 163 amino acid multi-pass membrane protein that contains two N-linked glycosylation sites and four transmembrane domains. Expressed ubiquitously with highest expression in peripheral blood leukocytes, EMP-3 is a myelin-related protein that is thought to be involved in cell-cell interactions and cell proliferation. The gene encoding EMP-2 is implicated as a possible tumor suppressor that silences CpG promotor action, thereby inhibiting the growth of neuroblastomas and gliomas. Overexpression of EMP-3, however, may be associated with the development of oligodendroglial tumors (tumors that develop on the myelin producing cells of the central nervous system). Its ability to both repress and induce tumor formation suggests that normal amounts of EMP-3 keep tumor activity low, while increased EMP-3 expression may play a role in carcinogenesis.