2292528-50mg 2292528-10mg
GW 9662
Biogems
DESCRIPTION
GW 9662 is an irreversible selective antagonist of PPARgamma, which regulates fatty acid storage and glucose metabolism. It is a more potent alternative to the BADGE molecule and is reported to have anticancer properties and to be useful in blocking the differentiation of monocytes to osteoclasts.
DETAILS
- Purity: ≥98%
- Synonyms: 2-Chloro-5-nitrobenzanilide, GW9662, GW-9662
- Cas Number: 22978-25-2
- References: Seargent, J. M., Yates, E. A., & Gill, J. H. (2004). GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation. British journal of pharmacology, 143(8), 933-937. Collino, M., Patel, N. S., Lawrence, K. M., Collin, M., Latchman, D. S., Yaqoob, M. M., & Thiemermann, C. (2005). The selective PPARγ antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney international, 68(2), 529-536. Wojtowicz, A. K., Szychowski, K. A., & Kajta, M. (2014). PPAR-γ agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells. Neurotoxicity research, 25(3), 311-322.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 2-chloro-5-nitro-N-phenylbenzamide
- Molecular Weight: 276.7
- Molecular Formula: C13H9ClN2O3
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl