DESCRIPTION

• Form: Antigen Affinity Purified
• Gene: S
• Host: Rabbit
• Rrid: AB_2868515
• Type: Primary Antibody
• Buffer: PBS + 50% glycerol and 5 mm NaN3
• Target: SARS-CoV-2 S-Protein ACE2 Binding Domain
• Isotype: IgG
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Shipping: Blue Ice
• Clonality: Polyclonal
• Immunogen: Recombinant SARS-CoV-2 S-Protein construct containing the ACE2 binding domain expressed in and purified from E. coli.
• Expiration: After date of receipt, stable for at least 1 year at -20°C.
• Specificity: Specific for the ~25 kDa ACE2 binding domain construct of SARS-CoV-2 S protein. Full-length CoV-2 S protein is ~142 kDa.
• Applications: WB, ICC
• Conjugate Exem: Unconjugated
• Physical State: Liquid
• Quality Control: Western blots performed on each lot.
• Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
• Molecular Weight: 25 or 142 full-length
• Production Notes: The antibody was purified over a column to which the protein antigen was coupled.
• Dilution Range Wb: 1:2000
• Immunogen Species: SARS-CoV2
• Dilution Range Icc: 1:1000
• Target Description: The novel SARS-coronavirus 2 (SARS-CoV-2) which causes the disease COVID-19 has been shown to utilize the SARS-CoV receptor ACE2 for entry into human cells (Hoffman, M. et al., Cell 2020). The entry of a coronavirus into host cells is mediated by the viral surface-anchored transmembrane spike (S) glycoprotein which is composed of two functional subunits, S1 which binds the receptor and S2 which fuses the membrane (Walls, AC et.al., Cell 2020). S1 contains a receptor-binding domain (RBD) which specifically recognizes ACE2 as its receptor (Wan, Y. et al., 2020).
• Uniprot Number Immunogen Species: P0DTC2

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