DESCRIPTION

• Form: Antigen Affinity Purified from Pooled Serum
• Gene: APP
• Host: Rabbit
• Rrid: AB_2492039
• Type: Primary Antibody
• Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Target: Amyloid Precursor Protein
• Isotype: IgG
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Shipping: Blue Ice
• Synonyms: A4 amyloid protein antibody, A4_HUMAN antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, AICD-50 antibody, AICD-57 antibody, AICD-59 antibody, AID(50) antibody, AID(57) antibody, AID(59) antibody, Alzheimer disease amyloid protein antibody, Amyloid beta (A4) precursor protein antibody, Amyloid beta A4 protein antibody, Amyloid beta protein antibody, Amyloid intracellular domain 50 antibody, Amyloid intracellular domain 57 antibody, Amyloid intracellular domain 59 antibody, Amyloid precursor protein antibody, APP antibody, APPI antibody, Beta amyloid peptide antibody, Beta-amyloid precursor protein antibody, Beta-APP40 antibody, Beta-APP42 antibody, C31 antibody, Cerebral vascular amyloid peptide antibody, CTFgamma antibody, CVAP antibody, Gamma-CTF(50) antibody, Gamma-CTF(57) antibody, Gamma-CTF(59) antibody, peptidase nexin II antibody, PN 2 antibody, PN II antibody, PN-II antibody, PN2 antibody, PreA4 antibody, Protease nexin II antibody, Protease nexin-II antibody, S-APP-alpha antibody, S-APP-beta antibody
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat APP, conjugated to keyhole limpet hemocyanin (KLH).
• Expiration: After date of receipt, stable for at least 1 year at -20°C.
• Specificity: Specific for endogenous levels of the ~115 kDa APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen.
• Applications: WB
• Ncbi Gene Id: 54226
• Conjugate Exem: Unconjugated
• Physical State: Liquid
• Quality Control: Western blots performed on each lot.
• Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
• Molecular Weight: 115
• Production Notes: Prepared from rabbit serum by affinity purification on a column made with the C-terminal peptide used as antigen.
• Dilution Range Wb: 1:1000
• Immunogen Species: Rat
• Species Reactivity: Mouse and Rat
• Target Description: A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).
• Expected Reactivity: Canine, Chicken, Human, Non-Human Primate
• Dilution Range Wb Brain: 1:1000
• Uniprot Number Immunogen Species: P08592

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