mouse monoclonal IgG1; Brn-3c Antibody (QQ8) is an IgG1 κ mouse monoclonal Brn-3c antibody (also designated POU4F3 antibody) that detects the Brn-3c protein of mouse, rat and human origin by WB, IP, IF and ELISA. Brn-3c Antibody (QQ8) is available as the non-conjugated anti-Brn-3c antibody. The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU (Pit-Oct-Unc) domain proteins, whereas Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor. Interestingly, Brn-3a has two functional transactivating domains, one at the amino-terminus and one at the carboxy-terminus. Brn-2 is thought to be involved in smooth muscle cell development and differentiation.